An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of human in vitro model systems, such as human pluripotent stem cell‐derived tissue, have led to a growing understanding of the mechanisms governing human lung development. They have illuminated key differences between animal models and humans, underscoring the need for continued advancements in modeling human lung development and utilizing (...) human tissue. This review discusses the use of human tissue and the use of human in vitro model systems that have been leveraged to better understand key regulators of human lung development and that have identified uniquely human features of development. This review also examines the implementation and challenges of human model systems and discusses how they can be applied to address knowledge gaps. (shrink)

Erasmus wrote his Colloquies as educational material for training boys in Latin conversation. This volume of the Amsterdam edition of the Latin texts of Erasmus offers a critical edition of the Latin texts of these influential, creative writings, which resemble short Latin plays.

Although the evidence remains tentative at best, the conception of hallucinations in schizophrenia as being underconstrained perception resulting from intrinsic thalamocortical resonance in sensory areas might complement current models of hallucination. However, in itself, the approach falls short of comprehensively explaining the neurogenesis of hallucinations in schizophrenia, as it neglects the role of external attributional biases, mental imagery, and a disconnection between frontal and temporal areas.

Music can reduce stress and anxiety, enhance positive mood, and facilitate social bonding. However, little is known about the role of music and related personal or cultural variables in maintaining wellbeing during times of stress and social isolation as imposed by the COVID-19 crisis. In an online questionnaire, administered in 11 countries, participants rated the relevance of wellbeing goals during the pandemic, and the effectiveness of different activities in obtaining these goals. Music was found to be the most effective activity (...) for three out of five wellbeing goals: enjoyment, venting negative emotions, and self-connection. For diversion, music was equally good as entertainment, while it was second best to create a sense of togetherness, after socialization. This result was evident across different countries and gender, with minor effects of age on specific goals, and a clear effect of the importance of music in people's lives. Cultural effects were generally small and surfaced mainly in the use of music to obtain a sense of togetherness. Interestingly, culture moderated the use of negatively valenced and nostalgic music for those higher in distress. (shrink)

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

The hexagonal structure for ‘the geometry of logical opposition’, as coming from Aristoteles–Apuleius square and Sesmat–Blanché hexagon, is presented here in connection with, on the one hand, geometrical ideas on duality on triangles (construction of ‘companion’), and on the other hand, constructions of tripartitions, emphasizing that these are exactly cases of borromean objects. Then a new case of a logical interest introduced here is the double magic tripartition determining the semi-ring ${\mathcal{B}_3}$ and this is a borromean object again, in the (...) heart of the semi-ring ${{\rm Mat}_{3}(\mathbb{B}_{\rm Alg})}$ . With this example we understand better in which sense the borromean object is a deepening of the hexagon, in a logical vein. Then, and this is our main objective here, the Post-Mal’cev full iterative algebra ${\mathbb{P}_4 = \mathbb{P}(\mathbb{F}_4)}$ of functions of all arities on ${\mathbb{F}_4}$ , is proved to be a borromean object, generated by three copies of ${\mathbb{P}_2}$ in it. This fact is induced by a hexagonal structure of the field ${\mathbb{F}_4}$ . This hexagonal structure is seen as precisely a geometrical addition to standard boolean logic, exhibiting ${\mathbb{F}_4}$ as a ‘boolean manifold’. This structure allows to analyze also ${\mathbb{P}_4}$ as generated by adding to a boolean set of logical functions a very special modality, namely the Frobenius squaring map in ${\mathbb{F}_4}$ . It is related to the splitting of paradoxes, to modified logic, to specular logic. It is a setting for a theory of paradoxical sentences, seen as computations of movements on the bi-hexagonal link among the 12 classical logics on a set of 4 values. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Eating Disorders and Mimetic Desire René Girard Stanford University Among younger women, eating disorders are reaching epidemic proportions. The most widespread and spectacular at this moment is the most recently identified, the so-called bulimia nervosa, characterized by binge eating followed by "purging," sometimes through laxatives or diuretics, more often through self-induced vomiting. Some researchers claim that, in American colleges, at least one third of the female student population (...) is involved to some degree. (Since nine out of ten sufferers are women I will use feminine pronouns in this paper but some undergraduates at Stanford tell me that the epidemic is spreading to male students.) G.M.F. Russell, the first researcher who focused on the specific aspects ofmodern bulimia, is usually presented as the discoverer of a new illness. The title ofhis 1979 publication contradicts this view: "Bulimia Nervosa: An Ominous Variant ofAnorexiaNervosa." And, indeed, all the symptoms he describes had been mentioned before in connection with anorexia (see Bruch). The insurance companies and the medical profession like only welldefined illnesses, and so does the public. We all try to distance ourselves from pathological contamination by giving it a name. Eating disorders are often discussed as ifthey were new varieties ofmeasles or oftyphoid fever. Why distrust the distinction between two illnesses with symptoms as radically opposed as those of anorexia and bulimia? Because we live in a world where eating too much and not eating enough are opposite but inseparable ways ofcoping with the slenderness imperative that dominates 2 René Girard our collective imaginations. Most of us oscillate all our lives between attenuated forms ofthese two pathologies. The man in the street understands perfectly a truth that most specialists prefer not to confront. Our eating disorders are caused by our compulsive desire to lose weight. Most books on the subject acknowledge the universal calorie phobia but somewhat absent-mindedly, as if it could not be the major cause ofa serious illness. How could a fundamentally healthy desire become the cause ofpathological behavior, even ofdeath? Many people would be healthier, no doubt, ifthey ate less. In view of this fact, it is not illogical to suppose that, in anorexia, there must be some motivation other than this healthy desire, some unconscious drive, no doubt, that generates abnormal behavior. By turning anorexia and bulimia into two separate pathologies, the classificators make it easier for us to lose sight of their common basis. The bankruptcy of modern theories The search for hidden motivations is the alpha and omega, ofcourse, of our modern culture. Our number one principle is that no human phenomenon is really what it seems to be. A satisfactory interpretation must rely on one of the hermeneutics of suspicion that have become popular in the nineteenth and twentieth century, or on several ofthese, on a cocktail of soupçon: psychoanalysis, Marxism, feminism, etc. We automatically assume that social phenomena have little if anything to do with what is obvious in them, in this case the rejection offood. In anorexia, psychoanalysts usually diagnose "a refusal of normal sexuality," due to the patient's excessive desire "to please her father," etc. These explanations are still invoked in books being written right now but the voice is growing fainter. Around this sort of thing the smell of mustiness is overpowering. Even in Lacan's own land, the old arrogance is gone. Early in my life, I had an opportunity to observe that the eating practices ofyoung women have nothing to do with a desire to please their fathers. Just before World War II, a pretty cousin of mine was dieting furiously and her father, my uncle, was storming about helplessly, trying to get her to eat more. Fathers, as a rule, are not pleased to see their daughters starve themselves. This particular father was also a physician, at a time when the medical profession had not yet caught the disease it was already trying to cure. Eating Disorders andMimetic Desire3 This uncle was our family doctor and, as such, had great prestige in my eyes, at least until that day. I had not yet read Freud but my later skepticism regarding his conception offatherhood may well originate in this incident. I immediately... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Eating Disorders and Mimetic Desire René Girard Stanford University Among younger women, eating disorders are reaching epidemic proportions. The most widespread and spectacular at this moment is the most recently identified, the so-called bulimia nervosa, characterized by binge eating followed by "purging," sometimes through laxatives or diuretics, more often through self-induced vomiting. Some researchers claim that, in American colleges, at least one third of the female student population (...) is involved to some degree. (Since nine out of ten sufferers are women I will use feminine pronouns in this paper but some undergraduates at Stanford tell me that the epidemic is spreading to male students.) G.M.F. Russell, the first researcher who focused on the specific aspects ofmodern bulimia, is usually presented as the discoverer of a new illness. The title ofhis 1979 publication contradicts this view: "Bulimia Nervosa: An Ominous Variant ofAnorexiaNervosa." And, indeed, all the symptoms he describes had been mentioned before in connection with anorexia (see Bruch). The insurance companies and the medical profession like only welldefined illnesses, and so does the public. We all try to distance ourselves from pathological contamination by giving it a name. Eating disorders are often discussed as ifthey were new varieties ofmeasles or oftyphoid fever. Why distrust the distinction between two illnesses with symptoms as radically opposed as those of anorexia and bulimia? Because we live in a world where eating too much and not eating enough are opposite but inseparable ways ofcoping with the slenderness imperative that dominates 2 René Girard our collective imaginations. Most of us oscillate all our lives between attenuated forms ofthese two pathologies. The man in the street understands perfectly a truth that most specialists prefer not to confront. Our eating disorders are caused by our compulsive desire to lose weight. Most books on the subject acknowledge the universal calorie phobia but somewhat absent-mindedly, as if it could not be the major cause ofa serious illness. How could a fundamentally healthy desire become the cause ofpathological behavior, even ofdeath? Many people would be healthier, no doubt, ifthey ate less. In view of this fact, it is not illogical to suppose that, in anorexia, there must be some motivation other than this healthy desire, some unconscious drive, no doubt, that generates abnormal behavior. By turning anorexia and bulimia into two separate pathologies, the classificators make it easier for us to lose sight of their common basis. The bankruptcy of modern theories The search for hidden motivations is the alpha and omega, ofcourse, of our modern culture. Our number one principle is that no human phenomenon is really what it seems to be. A satisfactory interpretation must rely on one of the hermeneutics of suspicion that have become popular in the nineteenth and twentieth century, or on several ofthese, on a cocktail of soupçon: psychoanalysis, Marxism, feminism, etc. We automatically assume that social phenomena have little if anything to do with what is obvious in them, in this case the rejection offood. In anorexia, psychoanalysts usually diagnose "a refusal of normal sexuality," due to the patient's excessive desire "to please her father," etc. These explanations are still invoked in books being written right now but the voice is growing fainter. Around this sort of thing the smell of mustiness is overpowering. Even in Lacan's own land, the old arrogance is gone. Early in my life, I had an opportunity to observe that the eating practices ofyoung women have nothing to do with a desire to please their fathers. Just before World War II, a pretty cousin of mine was dieting furiously and her father, my uncle, was storming about helplessly, trying to get her to eat more. Fathers, as a rule, are not pleased to see their daughters starve themselves. This particular father was also a physician, at a time when the medical profession had not yet caught the disease it was already trying to cure. Eating Disorders andMimetic Desire3 This uncle was our family doctor and, as such, had great prestige in my eyes, at least until that day. I had not yet read Freud but my later skepticism regarding his conception offatherhood may well originate in this incident. I immediately... (shrink)

En primer término se analiza brevemente el contexto que posibilita en García Lorca la búsqueda de un nuevo lenguaje poético durante su estadía en Nueva York entre 1929-1930. Posteriormente se analiza el concepto de flâneur. Para ello se consideran las elaboraciones que desarrolló Walter Benjamin a propósito de la experiencia de Charles Baudelaire frente a las transformaciones urbanas y sociales que sufrió París a mediados del siglo XIX, durante el Segundo Imperio en Francia. Finalmente se indaga en la eventual configuración (...) de la figura del flâneur en Poeta en Nueva York de Federico Garcia Lorca. First of all, it’s analyzed briefly the context that makes possible in García Lorca the search of a new poetic language during his stay in New York between 1929 and 1930. Subsequently it’s analyzed the concept of flâneur. Because of that, it must be taken into account the devise that Walter Benjamin explained according to Charles Baudelaire’s experience against the urban and social transformations that hit Paris in the 19th century during the Second French Empire. Finally it makes inquiries in the possible configuration of the flâneur in Poeta en Nueva York by Federico García Lorca. (shrink)

En 1893, « physicien-ingénieur » André Blondel invente l’oscillographe bifilaire permettant de visualiser les tensions et courants variables. À l’aide de ce puissant moyen d’investigation, il entreprend tout d’abord l’étude des phénomènes de l’arc électrique alors utilisé pour l’éclairage côtier et urbain puis de l’arc chantant employé comme émetteur d’ondes radioélectriques en T.S.F. En 1905, il met en évidence un nouveau type d’oscillations non-sinusoïdales au sein de l’arc chantant. Vingt ans plus tard, Balthasar Van der Pol reconnaitra qu’il s’agissait en (...) réalité d’oscillations de relaxation. Pour expliquer ce phénomène, il fait appel à une representation dans le plan de phase et montre que son évolution prend la forme de petits cycles. Pendant le premier conflit mondial la triode remplace peu à peu l’arc chantant dans les systèmes de transmission. Au sortir de la guerre, Blondel transpose à la triode la plupart de ses résultats par analogie avec l’arc chantant. En avril 1919, il publie un long mémoire dans lequel il introduit la terminologie « oscillations auto- entretenues » et propose d’illustrer ce concept à partir de l’exemple du vase de Tantale qui sera ensuite repris par Van der Pol et par Philippe Le Corbeiller. Il fournit alors une définition d’un système auto-entretenu assez proche de celles qui seront données par la suite par Aleksandr’ Andronov et Van der Pol. Pour étudier la stabilité des oscillations entretenues par la triode et par l’arc chantant il utilise cette fois une représentation dans le plan complexe et explicite l’amplitude en coordonnées polaires. Il justifie alors l’entretien des oscillations par l’existence de cycles qui présentent presque toutes les caractéristiques des cycles limites de Poincaré. Enfin, en novembre 1919, Blondel réalise, un an avant Van der Pol, la mise en équation des oscillations d’une triode. En mars 1926, Blondel établit l’équation différentielle caractérisant les oscillations de l’arc chantant, en tous points similaire à celle qu’obtient concomitamment Van der Pol pour la triode. Ainsi, tout au long de sa carrière, Blondel, a apporté une contribution fondamentale et relativement méconnue à l’élaboration de la théorie des oscillations non linéaires. L’objet de cet article est donc d’analyser ses principaux travaux dans ce domaine et de mesurer leur importance, voire leur influence en les replaçant dans la perspective du développement de cette théorie. (shrink)

Si vous avez un jour hésité entre « F » et « M » en remplissant un formulaire, si enceinte de plus de huit mois et entrant dans un taxi on vous a appelé « Monsieur », si votre attirance pour le « sexe opposé » vous semble au contraire relever bizarrement davantage de l’homosexualité que de l’hétérosexualité, et si en plus vous êtes intéressé par les choses du corps, de la biologie et de la génétique, alors vous serez passionné (...) par cet ouvrage. Mais si vous vivez votre sexe physique et votre g... (shrink)

“Every surgeon carries within himself a small cemetery where from time to time he goes to pray—a place of bitterness and regret, where he must look for an explanation of his failures” René Leriche,...

Girard discusses "homosexuality" on three occasions in his oeuvre. Late in the first chapter of Deceit, Desire, & the Novel he discusses the relationship between Veltchaninov and Troussotsky, characters in Dostoyevsky's The Eternal Husband. Then in Part III of Things Hidden since the Foundation of the World the sections entitled "Homosexuality" and "Mimetic Latency and Rivalry" are dedicated to the subject. Indeed, in the latter of these Girard reproduces his discussion of Veltchaninov and Troussotsky from the earlier book. Finally, he (...) touches on the matter in Chapter 4 of A Theater of Envy: William Shakespeare, dedicated to... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A PARABLE OF SCANDAL: SPECULATIONS ABOUT THE WHEAT AND THE TARES IN MATTHEW 13 John F. Cornell St. John's College, NM I will open my mouth in parables; I will utter things kept secret since the foundation of die world" (Matthew 13:35) The title ofone of René Girard's path-breaking books, Things Hidden since the Foundation ofthe World, is of course drawn from this passage. Few scholarly writings compare (...) to this discussion ofmimetic rivalry and collective persecution for conveying a sense of the Bible's depths and secrecy, and for deciphering the wisdom inscribed in its images. Yet it is curious that Girard eschews the parables said to be the repositories of scriptural secrets. Both in Things Hidden (189) and in Quand ces choses commenceront (171-172), he distances himself from the parables as conceding too much to the human desire for a mythical God ofretribution. In light of all we have learned from Girard about our traditional misreadings of the Gospel, we might well question even the strongest impressions left by some of its figures. Might the parables' language of apocalyptic vengeance conceal a different revelation, just as an innocent death on a cross should disclose not the bloodlust ofa deity but the violence ofmen? Matthew's Jesus tells a story about a sowerwhose crop was infested by his enemy's weeds, weeds to be uprooted and destroyed at the harvest. And, granted, when Jesus translates the parable for the disciples he describes divine violence at the end ofhistory. The enemy is the devil and the sower is the Son ofMan who sends out his angels to discern the unrighteous ofhumanity and cast them into the furnace. But something does not seem quite right. Isn't Jesus' reduction of his own parable a little too obvious? And is there not John F. Cornell99 something grotesque—or at least simple-minded—about the teacher who warned about dirowing pearls ofwisdom now turning around and broadcasting the solution to one of the great mysteries? If we look closely at the very parable that surrounds the suggestion of "things hidden since the foundation ofthe world," we may see, however, that something is indeed hidden, hidden in the text. And what is hidden there confirms Girard's insight about the dominion ofmimetic rivalry since the world began. The Wheat and Tares is more than amyth ofdivine punishment. It is a parable ofthe essential human malady, a parable ofscandal. Here is the main text of the parable of the Wheat and the Tares, from Matthew chapter 13, in the New King James Version.1 "The kingdom ofheaven is like a man who sowed good seed in his field (agroi) but while men slept, his enemy came and sowed tares among the wheat and went his way. But when the grainhad sprouted and produced a crop, then the tares also appeared. So the servants of the [master of the house] (oikodespotou) came and said to him, 'Sir, did you not sow good seed inyourfield? How then does it have tares?' He said to diem, 'An enemy, [a man,] has done this.' The servants said to him, 'Do you want us then to go and gather them up?' But he said, 1No, lest while you gather up the tares you also uproot the wheat with them. Let both grow together until the harvest, and at the time ofharvest I will say to the reapers, "First gather together the tares and bind them in bundles to bum them, but gather the wheat into my bam.'"" (Matthew 13: 24-30) Andhere is the explanation ofdie Wheat and die Tares that follows soon after: All these things Jesus spoke to the multitude in parables; and without a parable He did not speak to them, that it might be fulfilled which was spoken by the prophet saying: "1 will open my mouth in parables; I will utter things kept secret [since] the foundation ofthe world." 1 Minor corrections, necessary to reflect the Greek, are indicated by brackets. The source for the Greek text is the Nestle-Almond Novum Testamentum Graece. 100A Parable ofScandal Then Jesus sent the multitude away and went into the house (oikiari). And His... (shrink)

When originally published in 1952, this book filled a gap in the history of philosophy and science and remains an important work today, because it puts the main mathematical and physical discoveries of Descartes in an accessible form, for the benefit of English readers. Descartes is acknowledged to be the founder of modern mathematics, through his invention of analytical geometry and this volume charts Descartes’ role in bringing a unity into algebra and geometry and the development of mathematics into a (...) discipline which could be properly analysed. Carefully paraphrasing the Géométrie, this volume retains much of Descartes’ original notation as well as the original diagrams. The volume also discusses the considerable contribution that Descartes made to the physical sciences which involved accurate work in optics, light, sight and colour. (shrink)

Kant as anthropologist forms the center of attention in this collection of four lectures delivered at Yale University in 1955: John E. Smith explores the connection between questions "What can I know?" "What ought I to do?" and "What may I hope?" and the fourth question, "What is man?" George E. Schrader follows Kant's concepts of human will and character through their development in existentialism. René Wellek describes Kant's place among the aestheticians who raised and treated the question of (...) the place of man and his works of art in the realms of beauty and purpose. And C. W. Hendel examines Kant's concepts of reason, faith, hope, duty, law, freedom, responsibility, and peace in the world of the French and American revolutions and in ours.--R. F. T. (shrink)

This collection of 17 articles offers an overview of the philosophical activities of a group of philosophers (who have been) working at the Groningen University. The meta-methodological assumption which unifies the research of this group, holds that there is a way to do philosophy which is a middle course between abstract normative philosophy of science and descriptive social studies of science. On the one hand it is argued with social studies of science that philosophy should take notice of what scientists (...) actually do. On the other hand, however, it is claimed that philosophy can and should aim to reveal cognitive patterns in the processes and products of scientific and common sense knowledge. Since it is thought that those patterns can function as guidelines in new research and/or in research in other disciplines, philosophy can nevertheless hold on to the normative aim which is characteristic of 'classical' philosophy of science. Compared to this common assumption, there is a diversity of subjects. Some papers deal with general problems of science, knowledge, cognition and argumentation, others with topics relating to foundational problems of particular sciences. Therefore this volume is of interest to philosophers of science, to philosophers of knowledge and argumentation in general, to philosophers of mind, as well as for scientists working in the physical and applied sciences, biology, psychology and economy who are interested in the foundations of their disciplines. After a foreword by Leszek Nowak and a general introduction by the editors, the book is divided into four parts, with special introductions. - I: Conceptual Analysis in Service of Various Research Programmes (Henk Zandvoort, Rein Vos, Rick Looijen, Gerben Stavenga, Renée Dalitz); - II: The Logic of the Evaluation of Arguments, Hypotheses, Default Rules, and Interesting Theorems (Erik Krabbe, Theo Kuipers, Alfons Keupink, Maarten Janssen/Yao-Hua Tan, Bert Hamminga); - III: Three Challenges to the Truth Approximation Programme (Sjoerd Zwart, Hinne Hettema/Theo Kuipers, Roberto Festa); - IV: Explicating Psychological Intuitions (Anne-Ruth Mackor, Jeanne Peijnenburg, Lex Guichard, Michel ter Hark). The Groningen research group was recently qualified, by an official international assessment committee, as one of the best philosophy research groups in the Netherlands. (shrink)